<narrative xml:lang="en">Refining Interventions to Reduce AIDS Mortality from Bacterial and Fungal Infections in Africa</narrative>

ZA-CIP-1997-015443-07-NIHR303140

Wits Health Consortium (Pty) Ltd

<narrative xml:lang="en">Refining Interventions to Reduce AIDS Mortality from Bacterial and Fungal Infections in Africa</narrative> To determine the burden, aetiological causes of, and risk factors for bacterial bloodstream infections and meningitis, relative to cryptococcosis and TB, in a national cohort of adult inpatients with AHD in South Africa. To evaluate fluconazole and flucytosine treatment for cryptococcal antigenaemia in a randomised-controlled trial (EFFECT), with added-value qualitative-methods research studies guided by PPI/E. To evaluate novel quantitative molecular assays for risk stratification of subclinical cryptococcosis and early diagnosis of histoplasmosis/ emergomycosis among adult inpatients and outpatients with AHD in Africa

NIHR

2018632